https://www.biorxiv.org/content/10.1...619v1.full.pdf
Quote:
Our data demonstrate that both monovalent and bivalent mRNA boosters markedly
increased antibody responses but did not substantially augment T cell responses. BA.5 NAb
titers were comparable following monovalent and bivalent mRNA boosters, with a modest and
nonsignificant trend favoring the bivalent booster by a factor of 1.3. These findings are
consistent with data recently reported for a BA.1-containing bivalent mRNA booster.
Our findings suggest that immune imprinting by prior antigenic exposure5 may pose a greater
challenge than currently appreciated for inducing robust immunity to SARS-CoV-2 variants.
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wow. To translate:
-Immune systems respond to injection, but doesn't translate to protection
-Immune systems are over-trained and can't learn new trick offered by bivalent
If only someone had warned us in advance!